https://www.tandfonline.com/doi/full/10.2147/IJGM.S421835

Interleukins (IL) Gene:

IL-1α -889 C>T (rs1800587) IL-1α +4845 G>T (rs17561) IL-1β -511 (rs16944) IL-6 -572 G>C (rs1800796), -174 G>C (rs1800795), -597 G>A (rs1800797) IL-8 -251 T>A (rs4073)

Tumor Necrosis Factor (TNF) Gene:

TNF-α -308 G>A (rs1800629) TNF-α -238 G>A (rs361525) TNF-α -857 (rs1799724) TNF-α -1031 (rs1799964) TNF-α -863 (rs1800630) TNFRSF1B T>G (rs1061622)

Resistin Gene (RETN):

RETN +299 G>A (rs3745367) RETN -420 C>G (rs1862513)

CYP Family Gene:

CYP17 -34 T/C (rs743572) CYP19A1 rs700518, rs2236722 CYP1A1 m1 allele

Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) Genes:

MMP-2 -1306 C/T (rs243865) TIMP-2 -418 G/C (rs8179090), rs4789932 TIMP-1 372C/T (rs4898)

Other Genes:

Insulin-like growth factor-1 (IGF-1) gene polymorphisms - likely rs35767 Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) -3928C/T Toll-like receptor 4 (TLR4) - rs4986790, rs4986791 (https://selfdecode.com/app/article/tlr4-acne) TLR2 +2258 G/A TGFB2 rs1256580, rs1159268 Androgen receptor (AR) CAG repeat polymorphism NLRP3, ACE I/D, MAPK11, SEMA4B, SELL, TRAF3IP2, TYK2, PPARG (https://selfdecode.com/app/article/pparg-acne), DDB2 (https://selfdecode.com/app/article/ddb2-acne/) genes Stress - skin tags, acne HSD11B1 T>G (rs12086634) (https://selfdecode.com/app/article/hsd11b1-cortisol-acne) FST (https://selfdecode.com/app/article/fst-acne-tgf) https://pubmed.ncbi.nlm.nih.gov/37113088/ GSTP1 A>G (rs1695) TP53 G>C (rs1042522) (edited)

OVOL1 11q13.1 (rs478304): Risk allele T FST 5q11.2 (rs38055): Risk allele A Navarini, Alexander A et al. “Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.” Nature communications vol. 5 4020. 13 Jun. 2014, doi:10.1038/ncomms5020

6:02 PM

MYC rs4133274 Risk allele on positive strand: G Zhang, Mingfeng et al. “A genome-wide association study of severe teenage acne in European Americans.” Human genetics vol. 133,3 (2014): 259-64. doi:10.1007/s00439-013-1374-4 (edited)

"Decreased ghrelin levels and GA and GG genotypes of GHRL gene rs27647 polymorphism may have a role in the pathogenesis of acne vulgaris." Pektas, S. D., Cinar, N., Duman, D. D., Kara, A., Batu, J., Karakas-Celik, S., & Aksoy, D. Y. (2020). The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris. Postepy dermatologii i alergologii, 37(5), 800–809. https://doi.org/10.5114/ada.2020.100492

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